Mild hypertension should not be combined with drugs
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Core tip: in the treatment of hypertension, combination therapy is the most popular method, but not all patients with hypertension are suitable. For people with mild hypertension (grade 1 hypertension), the blood pressure value is close to the target value, and only one drug is needed. After seeing the development of the patient's condition, consider whether to use combined drugs.
The famous hot study on hypertension points out that the effective rate of single drug is changed from 63% at first to 33% at last, while the effective rate of combined medication is increased to 93%. Indeed, the side effects of drugs are closely related to the dosage used, and the higher the dose, the higher the probability of side effects. Two or more drugs can have synergistic and antagonistic effects in vivo. Rational use can enhance the efficacy and reduce or even offset the side effects. Therefore, in the treatment of hypertension, the combination of drugs is currently more respected drug methods.
But not all patients with hypertension are suitable. There is a standard for the combination of drugs, that is, there should be a sufficient gap between the current blood pressure and the target blood pressure, that is, the systolic blood pressure difference is more than 20 mmHg, and the diastolic blood pressure difference is more than 10 mmHg.
For example, if the patient's current blood pressure value is 180 / 110 mmHg and the target is to reduce it to 140 / 90 mmHg, then his systolic blood pressure gap is 40 mmHg and diastolic blood pressure gap is 20 mmHg. In this case, it is suggested that the combination of drugs should be used, and the combination of small doses should be used first, and the effect of "1 + 1 > 2" can be brought into play.
Experts remind that for people with mild hypertension (grade 1 hypertension), the blood pressure value is close to the target value, so only one drug needs to be used, and whether combined medication is needed will be considered after seeing the doctor.
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