One was published in the international journal physiologic In the Research Report on genomics, scientists from the University of Illinois and other institutions have revealed the relationship between sleep disturbance, hypertension and intestinal microbiome changes. In this paper, the researchers aim to determine whether sleep disturbance for 28 days will change the microbiome in rats. Intestinal microbiome refers to the collection of microorganisms living in the intestine Researchers want to identify biological characteristics associated with poor arterial blood pressure changes.
Using rats for research, researchers interfered with the sleep cycle of rats, rats are nocturnal animals, so the experiment designed by the researchers can interfere with their daytime sleep cycle, and researchers use telemetry (telemetry) The rats' brain activity, blood pressure and heart rate were measured, and their feces were analyzed to find out the changes of intestinal flora. The researcher maki said that when the sleep cycle or plan of rats was abnormal, their blood pressure would increase. Even when the sleep cycle returned to normal, the body blood pressure would still maintain an elevated level, which indicated that the function was lost Sleep adjustment may damage the health of the body for a period of time.
In addition, the researchers also found undesirable changes in the intestinal microbiome of rats. Contrary to their initial hypothesis, they found that the changes in intestinal microbiome of rats did not occur rapidly, but took about a week to show adverse reactions, such as the imbalance between different types of bacteria, including the level of inflammation related bacteria And so on. When the sleep disturbance stopped in rats, everything did not seem to return to normal level immediately. This study revealed a complex system with many pathological factors.
This study is only a preliminary study. In the later stage, researchers will continue to study and analyze the related signaling pathways related to intestinal microbiome and metabolites produced by intestinal microflora. Researchers want to clearly reveal the mechanism of changes in sleep characteristics of the body, and how long the changes of body blood pressure and intestinal microbiome will last. At the same time, the researchers also want to further study the related signaling pathways The results were translated into human studies. Finally, researcher Fink said that we hope to find an intervention to help people with high risk of cardiovascular disease, because their work and sleep cycle are easily affected. Researchers believe that through later research, they can develop new therapies or change their diet to reduce the risk of cardiovascular disease